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KMID : 0366220160510030187
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Korean Journal of Hematology
2016 Volume.51 No. 3 p.187 ~ p.192
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Treatment outcomes of IMEP as a front-line chemotherapy for patients with peripheral T-cell lymphomas
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Lee Ji-Young
Lee Sang-Min
Choi Moon-Young
Kim Ki-Hyang
Joo Young-Don
Im Sung-Nam
Lee Won-Sik
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Abstract
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Background: This study aimed to assess the treatment outcomes of ifosphamide, mesna, etoposide, and prednisolone (IMEP) combination regimen as a front-line chemotherapy in patients with peripheral T-cell lymphomas (PTCLs).
Methods: Clinical data of 38 newly diagnosed PTCLs patients who underwent IMEP at Busan Paik Hospital from January 2002 to December 2013 were retrospectively analyzed.
Results: The overall response rate was 68.5%, with 21 (55.3%) complete response/complete response unconfirmed and 6 (15.8%) partial response (PR). The median follow-up duration was 25.5 months (range, 0.2-87.3). The median overall survival was not reached and 2-year survival rate was 67%. The median progression free survival was 23 months. The most frequently reported adverse effects higher than grade 3 were hematologic toxicities including neutropenia (68.4%), thrombocytopenia (42.1%). There was no treatment-related mortality.
Conclusion: IMEP regimen is effective and safe as a front-line chemotherapy in patients with PTCLs.
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KEYWORD
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Peripheral T-cell lymphomas, IMEP, Ifosphamide, Etoposide, Prednisolone
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